Sanguinarine-Dependent Induction of Apoptosis in Primary Effusion Lymphoma Cells
نویسندگان
چکیده
منابع مشابه
Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells.
Primary effusion lymphoma (PEL) is an incurable, aggressive B-cell malignancy that develops rapid resistance to conventional chemotherapy. In efforts to identify novel approaches to block proliferation of PEL cells, we found that sanguinarine, a natural compound isolated from the root plant Sanguinaria canadendid, inhibits cell proliferation and induces apoptosis in a dose-dependent manner in s...
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http://bloodjournal.hematologylibrary.org/content/101/6/2321.full.html Updated information and services can be found at: (4217 articles) Neoplasia (3667 articles) Clinical Trials and Observations (746 articles) Apoptosis Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information ...
متن کاملPrimary effusion lymphoma.
Primary effusion lymphoma (PEL) is a rare HIV-associated non-Hodgkin's lymphoma (NHL) that accounts for approximately 4% of all HIV-associated NHL. PEL has a unique clinical presentation in having a predilection for arising in body cavities such as the pleural space, pericardium, and peritoneum. PEL cells are morphologically variable with a null lymphocyte immunophenotype and evidence of human ...
متن کاملInhibition of phosphatidylinositol 3'-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells.
PURPOSE Phosphatidylinositol 3'-kinase (PI3'-kinase) can be activated by the K1 protein of Kaposi sarcoma-associated herpes virus (KSHV). However, the role of PI3'-kinase in KSHV-associated primary effusion lymphoma (PEL) is not known. To assess this, we studied survival and apoptosis in PEL cell lines following inhibition of PI3'-kinase. EXPERIMENTAL DESIGN Constitutive activation of several...
متن کاملInhibition of Phosphatidylinositol 3V-Kinase/AKTSignaling Promotes Apoptosis of Primary Effusion Lymphoma Cells
Purpose: Phosphatidylinositol 3V-kinase (PI3V-kinase) can be activated by the K1protein of Kaposi sarcoma ^ associated herpes virus (KSHV). However, the role of PI3V-kinase in KSHVassociated primary effusion lymphoma (PEL) is not known. To assess this, we studied survival and apoptosis in PEL cell lines following inhibition of PI3V-kinase. Experimental Design: Constitutive activation of several...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2007
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-06-3764